[Skip to content]

Database

The CASH Database

The database is the hub of the CASH service. The content can be added, searched and exported to create personalised alerting services for library customers.  There are a number of newsfeeds that can be embedded into external CAS website pages keeping them constantly updated with the latest content.

To search for a specific item enter a keyword that may appear in either the title or summary.

Database entry is very quick and easy, see the Database Quick Guide for further support.

Search Tips

  • Search for the first three words in the title e.g. "Five year forward" will find everything about the Five Year Forward View
  • Browse a category from the drop-down list to see the latest news on that topic

  • Enter a keyword to narrow your search e.g. Category Mental Health and Keyword Parity 

DAMPs and NETs in Sepsis

Source
Frontiers in Immunology
Year of publication
2019
Abstract
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host response to pathogens mediated through the interaction of pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs). PRRs are also activated by host nuclear, mitochondrial, and cytosolic proteins, known as damage-associated molecular patterns (DAMPs) that are released from cells during sepsis. Some well described members of the DAMP family are extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1), histones, and adenosine triphosphate (ATP). DAMPs are released from the cell through inflammasome activation or passively following cell death. Similarly, neutrophil extracellular traps (NETs) are released from neutrophils during inflammation. NETs are webs of extracellular DNA decorated with histones, myeloperoxidase, and elastase. Although NETs contribute to pathogen clearance, excessive NET formation promotes inflammation and tissue damage in sepsis. Here, we review DAMPs and NETs and their crosstalk in sepsis with respect to their sources, activation, release, and function. A clear grasp of DAMPs, NETs and their interaction is crucial for the understanding of the pathophysiology of sepsis and for the development of novel sepsis therapeutics.
Date added
28/11/2019
Created by
Sarah Thomas
Published by
Current Awareness Service for Health